Synthesis of Sialyl Lewis X Analogues |
| |
| Authors: | Gyula Dekany Karen Wright Peter Ward Istvan Toth |
| |
| Affiliation: | 1. The School of Pharmacy , University of London , 29–39 Brunswick Square, London, WC1N 1AX;2. Glaxo Group Research Ltd. , Greenford Road, Greenford, UB6 0RE, UK |
| |
| Abstract: | Abstract Sialyl Lewis X (SLex) analogs 2a and 2b were synthesised, where the N-acetyl-D-glucose and the D-galactose units of SLex 1 were replaced with an alkyl and a heteroalkyl spacer. Sulphate ester 6i was also synthesised from alcohol 6b and chlorosulphonic acid. A novel promoter, silver mercaptoethanesulphonate, was used to synthesise α-sialosides 2c. 7b and 7c. |
| |
| Keywords: | |
|
|
