Synthesis of 5-O-β-Iodoethyl-D-Glucofuranose |
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| Authors: | Christophe Morin Lionel Ogier |
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| Institution: | Department of Chemistry , Cleveland State University , Cleveland, Ohio, 4415 |
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| Abstract: | ABSTRACT The preparation of an iodinated derivative of D-glucose where a β-iodoethyl moiety has been introduced at O-5 is presented. In such an analogue the existence of pyranose forms is precluded and the iodinated tag lies in a region of the carbohydrate not judged essential for recognition by the glucose transport protein; also noteworthy in such a compound is the stability of the carbon-iodine bond, a prerequisite for its potential use in SPECT medical imaging. |
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