D-Glucosyl Kojic Acid Derivatives,Potential Precursors for the Cyclic Carboxylate Equivalents of Gaba Mimetic Agents |
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| Authors: | El Sayed H El Ashry Yeldez El Kilany Ahmed Mousaad |
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| Institution: | Chemistry Department, Faculty of Science , Alexandria University , Alexandria, Egypt |
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| Abstract: | Abstract Precursors for the cyclic carboxyl equivalents of γ-aminobutyric acid (GABA) were synthesized. 5-O-(2, 3, 4, 6-Tetra-O-acetyl-β-D-gluco-pyranosyl-2-4-phenyl-1, 2, 3-triazol-1-yl)methyl]-4H-pyran-4-one could be prepared by the glucosidation of 2-chloromethyl-5-hydroxy-4H-pyran-4-one. Nucleophilic displacement of the chlorine with azide ion gave the corresponding azidodeoxy derivative that upon 1, 3-dipolar cycloaddition with phenylacetylene yielded the triazolyl derivative. |
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