Synthesis of Deoxy and Deoxyhalogeno Analogues of myo-Inositol |
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| Authors: | Cong Jiang James D. Moyer David C. Baker |
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| Affiliation: | 1. Department of Chemistry , The University of Alabama , Tuscaloosa, AL, 35487-9671;2. Laboratory of Biological Chemistry , National Cancer Institute National Institutes of Health , Bethesda, MD, 20892 |
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| Abstract: | Abstract A number of deoxy and deoxyhalogeno analogues of moyo-inositol of Interest 1n Investigating the biochemical processes of the phosphoinositide pathway were synthesized. Syntheses Include those deoxyinositols (cyclohexane pentols) which correspond to myo-inositol deoxygenated at positions 1, 4 and 5, as well as a set of 5-deoxyhalogeno (F, Cl, Br, I) myo- and epimeric neo-inositols. Configurational assignments are based primarily on 1H NMR spectroscopy. |
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