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Curdlan as a Polymeric Starting Material to Access C6-Modified Glucose Derivatives |
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| Authors: | Tomoyuki Miyazawa Haruka Abe Takayuki Suzuki Yosuke Togashi Kazuhiro Koshiji Yuki Nonaka |
| Affiliation: | 1. Department of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun 374-0193, Japan;2. Graduate School of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun 374-0193, Japan;3. Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe 350-8585, Japan |
| Abstract: | We evaluated the potential of a linear β-1,3-glucan (curdlan) as a starting material to access C6-modified glucose derivatives and found that 6-bromo-6-deoxyglucose, 6-azide-6-deoxyglucose, and 6-acetamido-6-deoxyglucose could be readily prepared from curdlan through its C6-selective and quantitative modifications and subsequent acid-catalyzed hydrolysis. |
| Keywords: | Curdlan Regioselective Modifications Hydrolysis C6-modified glucoses |