A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl |
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| Authors: | Shengjun Huang Jun Liao Qingjie Zhao Xiaoyun Chai Baogang Wang Shichong Yu |
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| Institution: | Department of Organic Chemistry, School of Pharmacy , Second Military Medical University , Shanghai , 200433 , People's Republic of China |
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| Abstract: | TMSCl was shown to be an efficient reagent for selective deprotection of the anomeric position protected as N,O-dimethylhydroxylamine glycoside. This deprotection condition was proved to be compatible with a number of protecting groups, such as the TBDPS, acetyl, benzyl, benzylidene, and benzoyl groups. |
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| Keywords: | TMSCl N O-dimethylhydroxylamine Anomeric protection Anomeric deprotection |
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