Synthesis of Protein Conjugates of 2-Carboxy-L-Arabinitol 5-Phosphate and 2-Carboxy-L-Ribitol 5-Phosphate |
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| Authors: | Nelly Gourlaouën Dominique Florentin Andrée Marquet |
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| Institution: | Laboratoire de Chimie Organique Biologique , URA CNRS 493 Université , P. et M. Curie – 4 place Jussieu, Tour 44-45, 75252, Paris Cedex 05, France Fax: E-mail: marquet@ccr.jussieu.fr |
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| Abstract: | Abstract The synthesis of 5-O-5-(pentanoic acid)]-phosphono-L-erythro-pent-2-ulose 2 was successfully achieved by coupling benzyl 5-hydroxypentanoate 9b and 1-O-benzyl-L-erythro-pent-2-ulose ethane- 1,2-diyl dithioacetal 13 with the enediol pyrophosphate 18. Compound 2 was coupled to carrier proteins, porcine thyroglobuline and bovine serum albumin and the conjugates were treated with KCN to give conjugates of the hapten 1, designed to raise catalytic antibodies. |
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