Open Chain Chiral Macrolide Building Blocks by Opening of Deoxygenated 1,6-Anhydrosugars with 1,3-Propanedithiol |
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| Authors: | Karsten Krohn Ishtiaq Ahmed Dietmar Gehle Mohammed Al Sahli |
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| Institution: | Department of Chemistry , University of Paderborn , Paderborn, Germany |
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| Abstract: | Chiral building blocks for macrolides and related natural products are obtained from 1,6-anhydrosugars by conversion of the bicyclic acetals 2 or 12 into the open chain chiral 1,3-dithianes 6 and 13. Branched precursors can be obtained by opening of the ?erný epoxide 1 with the 1,3-dithiane anion to yield 7, followed by ring opening with 1,3-propanedithiol to the bis-1,3-dithiane 8. |
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| Keywords: | 1 6-Anhydrosugars Chiral building blocks Ring opening with 1 3-propandithiol 1 3-Dithianes ?erný epoxides |
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