Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens |
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| Authors: | Anatoly Ya Chernyak Leonid O Kononov Nikolay K Kochetkov |
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| Institution: | N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Leninsky prospect 47, 117913, Moscow, Russia |
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| Abstract: | Abstract Galacturonamides of amino acids (alanine, lysine, serine, and threonine), constituents of Proteus O-specific polysaccharides, have been synthesised. O-tert-Butyl and N?-tert-butyloxycarbonyl protected amino acid tert-butyl esters were condensed with the 2-azidoethyl α-glycoside of d-galacturonic acid, prepared by Fischer glycosidation. Reduction of the azido group followed by N-acryloylation and deprotection gave the target monomers. By copolymerisation with acryl-amide, these were converted into glycopolymers potentially useful for defining epitopes in Proteus O-antigens. |
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