Triflic Anhydride: An Alternative Promoter in Glycosidations |
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Authors: | Alicia Dobarro-Rodriguez Michel Trumtel Hans Peter Wessel |
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Affiliation: | Pharma Division , Preclinical Research F. Hoffmann-La Roche Ltd , CH, 4002, Basel, Switzerland |
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Abstract: | Abstract The activation of glucosyl halides, trichloroacetimidates and of thioglucosides with triflic anhydride has been investigated showing that triflic anhydride promotes glycos idations with trichloracetimidates as well as with fluorides. There is also some potential for the activation of reactive thioglycosides. The role of triflic anhydride as a Lewis acid is likely. |
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