An Improved Synthesis and NMR Spectra of Benzylated Glycals |
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Authors: | Marek Chmielewski Izabela Fokt Jacek Grodner Grzegorz Grynkiewicz Wieslaw Szeja |
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Institution: | 1. Institute of Organic Chemistry , Polish Academy of Sciences, 01-224, Warsaw, Poland;2. Silesian Technical University , 44-100, Gliwice, Poland;3. Institute of Pharmaceutical Industry , 01-793, Warsaw, Poland |
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Abstract: | Abstract Benzylated glycals, unlike their acylated congeners which easily undergo allylic rearrangement, are frequently employed as reactive enol ether type substrates in a variety of electrophilic addition reactions.1–4 Although these compounds are considered to be readily available substrates, reported procedures for their syntheses involve some steps of limited efficiency, chromatographic separations or costly reagents,5–7 and experimental requirements not amenable for large scale preparations. In view of the recent applications of benzylated glycals to syntheses of O-glycosides,1,2 C-glycosyl compounds,3 and β-lactams,4 we have undertaken a study aimed at efficient one step benzylation procedures applicable to pyranoid 1-enitols as well as to their acylated derivatives. This goal was eventually achieved by employing a catalytic phase transfer alkylation system with |
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