|
|||||
|
|
A Direct Route to a New Class of Acrylamide Thioglycosides |
|
| Authors: | Galal H Elgemeie Wafaa A Zaghary Kamelia M Amin Tamer M Nasr |
| Institution: | 1. Faculty of Science, Department of Chemistry , Helwan University , Cairo, Egypt elgemeie@yahoo.com;3. Faculty of Pharmacy, Pharmaceutical Chemistry Department , Helwan University , Cairo, Egypt;4. Faculty of Pharmacy, Pharmaceutical Chemistry Department , Cairo University , Cairo, Egypt |
| Abstract: | The preparation of a new class of acrylamide thioglycosides via one‐pot reaction of the potassium 2‐cyanoethylene‐1‐thiolate salts with 2,3,4,6‐tetra‐O‐acetyl‐α‐D‐gluco‐ and galactopyranosyl bromides has been studied. The E‐configuration of these thioglycosides was proven by their transformations to the corresponding 5‐aminopyrazoles. |
| Keywords: | Acrylamide thioglycosides Potassium 2‐cyanoethylene‐1‐thiolate salts 5‐Aminopyrazoles |