Synthesis of 5-Thio-D- Galactopyranose |
| |
| Authors: | Yuancheng Wang Yuguo Du |
| |
| Affiliation: | 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing , China;2. School of Chemistry and Chemical Engineering , University of Chinese Academy of Sciences , Beijing , China |
| |
| Abstract: | 5-Thio-D-galactopyranose has been synthesized from diacetone galactofuranose in nine steps and 13.4% overall yield. The key step involved a successful conversion of furanosyl 5,6-epoxide with an L-altrose configuration into the corresponding 5,6-thiirane D-galactose derivative, which was hydrolyzed to the target compound. |
| |
| Keywords: | 5-Thio-D-galactopyranose Glycosidase inhibitors Thiirane Galactofuranose Thiosugars |
|
|
