The Microbial Pathology of Neu5Ac and Gal Epitopes |
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| Authors: | Muhammad Ramzan Manwar Hussain Hani Asfour Muhammad Yasir Asifullah Khan Hussein Sheikh Ali Mohamoud Jumana Y Al-Aama |
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| Institution: | 1. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases , Department of Genetic Medicine, School of Medicine, King Abdulaziz University , Saudi Arabia;2. Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases , Department of Genetic Medicine, School of Medicine, King Abdulaziz University , Saudi Arabia;3. Department of Medical Microbiology and Parasitology, School of Medicine , King Abdulaziz University , Saudi Arabia;4. King Fahd Medical Research Center, King Abdulaziz University , Jeddah , Saudi Arabia;5. Department of Biochemistry, UCS Shankar Campus, Abdul Wali Khan University , Mardan , Pakistan |
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| Abstract: | Glycans play a vital role in modulating many physiological and pathological phenomena of microbes and humans, such as bacterial adhesion, colonization, host-microbial interactions, cancer recognition, and blood group determination. The aim of the current review is to provide an account of the functions of N-acetyl sialic acid (Neu5Ac) and galactose (Gal) residues in microbial pathology. Specifically, an overview of the biosynthesis and metabolism of Neu5Ac and Gal residues in different bacterial species will provide a better understanding of microbial pathogenesis in the human body. |
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| Keywords: | Sialic acid (Neu5Ac) Galactose Microbial pathology Group B Streptococcus Helicobacter pylori |
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