Asymmetric hydrogenation of aromatic ketones with MeO-PEG-supported BIPHEP/DPEN ruthenium catalysts |
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Authors: | Li-Ting Chai Wei-Wei Wang Quan-Rui Wang Feng-Gang Tao |
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Affiliation: | aDepartment of Chemistry, Fudan University, Shanghai 200433, PR China |
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Abstract: | A soluble polymer (MeO-PEG) supported biphenylbisphosphine (BIPHEP)-Ru/chiral diamine (1,2-diphenylethylenediamine) complex, in which the polymer is attached to the two phenyl rings of BIPHEP ligand, has been prepared, and shown to be highly active with good enantioselectivity for the catalyzed asymmetric hydrogenation of unfunctionalized aromatic ketones. The derived chiral ruthenium complex 5 proved to be stable in air allowing facile catalyst recycling. Especially for 4′-tert-butyl-acetophenone and 1-acetonaphthone, excellent ee values up to 96.5% and 95.9% have been obtained which are comparable to or even higher than the enantioselectivity achieved with 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl-Ru-DPEN catalyst under similar conditions. |
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Keywords: | MeO-PEG Supported catalyst Asymmetric hydrogenation Aryl ketones |
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