Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography |
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Authors: | Liu Feng-Hua Jiang Ye |
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Institution: | Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang City, China. |
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Abstract: | Using new solvent room temperature ionic liquid (IL) matrix media, testing of residual solvents in pharmaceutical preparations with static headspace gas chromatographic (SH-GC), is described. The purpose of this work was to demonstrate the feasibility of IL as diluent, six solvents utilized in synthesis of Adefovir Dipivoxil: acetonitrile, dichloromethane, N-methyl-2-pyrrolidone (NMP), toluene, dimethylformamide (DMF), n-butyl ether were dissolved in IL: 1-butyl-3-methylimidazolium tetrafluoroborate (bmim]BF(4)). The method of external standard was used for quantitative analysis. Its performance was evaluated and validated: all the RSD were lower than 10%, the limits of detection were all of the ppm level and the method was both accurate and linear. And better sensitivities for the six solvents were gained with bmim]BF(4) as diluent comparing with DMSO. |
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