Self-assembly of surfactant-like peptides |
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Authors: | Adams Dave J Holtzmann Kathrin Schneider Christian Butler Michael F |
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Affiliation: | Unilever Corporate Research, Colworth Science Park, Sharnbrook, Bedford, UK. dave.adams@unilever.com |
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Abstract: | Inspired by recent work describing surfactant-like peptides, we have carried out a systematic study on peptides with the underlying composition of V6D2, altering the absolute sequence to determine the importance of the surfactant-like structure. All of the peptides examined here formed self-assembled structures in water. However, in contrast to other reports, we have found a surprising diversity of structures including fibers, tapes, and twisted ribbons but an absence of the vesicles and nanotubes described previously. Further investigations demonstrated that peptide purity plays a significant role in the outcome of the self-assembly. Different batches behave very differently, which can be linked to the compositions of these batches. This work shows that there is a need for not only rational design but also ease of synthesis of the building blocks for self-assembled structures. |
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