A silyl-α-cyclodextrin intermediate. Preparation and characterization of dodeca-t-butyldimethylsilyl-hexahydroxy-α-cyclodextrin |
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| Authors: | Tomasz J. Michalski Ady Kendler Myron L. Bender |
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| Affiliation: | 1. Department of Chemistry, Northwestern University, 60201, Evaston, IL, USA
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| Abstract: | The title compound (II) was prepared by treating dry, purified α-cyclodextrin with 20 equivalents oft-butyldimethylsilyl chloride 20 hr at 110° in DMF/pyridine. Work-up of the product mixture gave 60%II, which was identified by1H and13C NMR. Treatment ofII with Bu4NF 6 hr in refluxing dry THF efficiently removed the protecting groups. |
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