Effects of exposure of chloroquine picrate to the sun: A differential scanning calorimetric study |
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Authors: | I O Edafiogho J R Mulokozi A M Mulokozi S Diete-Spiff |
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Institution: | (1) Department of Pharmacology, University of Sokoto, Sokoto, Nigeria;(2) Department of Chemistry, University of Sokoto, Sokoto, Nigeria |
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Abstract: | In a continuing study of the effect of exposure of chloroquine and its salt derivatives to the sun, the picrate was investigated. The picrate gives a sharp endothermic effect of melting at 209.2 °C, before it decomposes, to give an exothermic peak at 255.6 °C. The endothermic peak of melting at 209.2 °C was found suitable for the quantitative determination of chloroquine picrate in sun-exposed samples.
Zusammenfassung In Fortführung einer Untersuchung über Veränderungen von Chloroquin und dessen Derivaten, wenn diese der Sonne ausgesetzt werden, wurden die Pikrate untersucht. Bei den Pikraten werden ein scharfer, dem Schmelzvorgang zuzuschreibender Effekt bei 209.2 °C und ein mit der Zersetzung einhergehender exothermer Peak bei 255.6 °C beobachtet. Der endotherme Peak bei 209.2 °C erwies sich als geeignet zur quantitativen Bestimmung von Chloroquinpikrat in der Sonne ausgesetzten Proben.
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![rcy](/content/t487007606861312/xxlarge1088.gif) 255,6 ° ![pcy](/content/t487007606861312/xxlarge1087.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![rcy](/content/t487007606861312/xxlarge1088.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![ocy](/content/t487007606861312/xxlarge1086.gif) ![kcy](/content/t487007606861312/xxlarge1082.gif) ![ocy](/content/t487007606861312/xxlarge1086.gif) ![ncy](/content/t487007606861312/xxlarge1085.gif) ![chcy](/content/t487007606861312/xxlarge1095.gif) ![acy](/content/t487007606861312/xxlarge1072.gif) ![tcy](/content/t487007606861312/xxlarge1090.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![lcy](/content/t487007606861312/xxlarge1083.gif) ![softcy](/content/t487007606861312/xxlarge1100.gif) ![ncy](/content/t487007606861312/xxlarge1085.gif) ![ycy](/content/t487007606861312/xxlarge1099.gif) ![rcy](/content/t487007606861312/xxlarge1088.gif) ![acy](/content/t487007606861312/xxlarge1072.gif) 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![lcy](/content/t487007606861312/xxlarge1083.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![ncy](/content/t487007606861312/xxlarge1085.gif) ![icy](/content/t487007606861312/xxlarge1080.gif) ![pcy](/content/t487007606861312/xxlarge1087.gif) ![rcy](/content/t487007606861312/xxlarge1088.gif) 209,2 ° ![pcy](/content/t487007606861312/xxlarge1087.gif) ![rcy](/content/t487007606861312/xxlarge1088.gif) ![icy](/content/t487007606861312/xxlarge1080.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![mcy](/content/t487007606861312/xxlarge1084.gif) ![lcy](/content/t487007606861312/xxlarge1083.gif) ![iecy](/content/t487007606861312/xxlarge1077.gif) ![dcy](/content/t487007606861312/xxlarge1076.gif) ![lcy](/content/t487007606861312/xxlarge1083.gif) ![kcy](/content/t487007606861312/xxlarge1082.gif) ![ocy](/content/t487007606861312/xxlarge1086.gif) ![lcy](/content/t487007606861312/xxlarge1083.gif) ![icy](/content/t487007606861312/xxlarge1080.gif) 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