Design, synthesis and antitumor activity of a series of novel coumarin-stilbene hybrids, the 3-arylcoumarins |
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| Authors: | Chun Fen Xiao Li Yang Tao Hong Yi Sun Wen Wei Yu Chen Li Wu Fu Yong Zou |
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| Institution: | a Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China;b Graduated School of Chinese Academy of Sciences, Beijing 100049, China;c Oncology Research Department of Sun Yat-Sen University Cancer Center, Guangzhou 510060, China |
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| Abstract: | A series of novel coumarin-stilbene hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents. The results showed that some compounds exhibited in vitro activity against KB, KV, MCF-7, MCF-7/ADR cell lines to some extent. Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18 μmol/L. |
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| Keywords: | Perkin reaction 3-Arylcoumarin Trans-stilbene Antitumor activity |
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