| Synthesis of 4—Aryl—3,4—dihydropyrimidinones Using Microwaveassisted Solventless Biginelli Reaction |
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| 引用本文： | 薛松,申晏才,李亚莉,沈小明,郭庆祥. Synthesis of 4—Aryl—3,4—dihydropyrimidinones Using Microwaveassisted Solventless Biginelli Reaction[J]. 中国化学, 2002, 20(4): 385-389. DOI: 10.1002/cjoc.20020200417 |
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| 作者姓名： | 薛松 申晏才 李亚莉 沈小明 郭庆祥 |
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| 作者单位： | XUE，Song SHEN，Yan-Cai LI，Ya-Li SHEN，Xiao-Ming GUO，Qing-XiangDepartment of Chemistry，University of Science and Technology of China，Hefei，Anhui 230026，China |
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| 基金项目： | theResourceResearchBaseFoundationofUniversityofScienceandTechnologyofChinaandtheNationalNaturalScienceFoundationofChina (No.2 9972 0 38) |
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| 摘 要： | Ｉｎｔｒｏｄｕｃｔｉｏｎ4 Ａｒｙｌ 3,4 ｄｉｈｙｄｒｏｐｙｒｉｍｉｄｉｎｏｎｅｓ (4)ａｓａｃｏｒｅｗｅｒｅｏｂｓｅｒｖｅｄｉｎｓｏｍｅｂｉｏｌｏｇｉｃａｌｌｙｉｍｐｏｒｔａｎｔｃｏｍｐｏｕｎｄｓ .1Ｍｏｒｅｒｅｃｅｎｔｌｙ ,ｄｉｈｙｄｒｏｐｙｒｉｍｉｄｉｎｏｎｅｓａｒｅｓｈｏｗｎｔｏｂｅａｕｓｅｆｕｌｔｏｏｌｆｏｒｓｔｕｄｙｉｎｇｄｙｎａｍｉｃｃｅｌｌｕｌａｒｐｒｏｃｅｓｓａｎｄｃａｎｂｅｃｏｎｓｉｄｅｒｅｄａｓａｎｅｗｌｅａｄｆｏｒｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆａｎｔｉ ｃａｎｃｅｒｄｒｕｇ…
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| 关 键 词： | 合成 4－芳基－3，4－二氢嘧啶酮 苯甲醛 |
Synthesis of 4-Aryl-3,4-dihydropyrimidinones Using Microwave-assisted Solventless Biginelli Reaction |
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| XUE,Song SHEN,Yan-Cai LI,Ya-Li SHEN,Xiao-Ming GUO,Qing-Xiang. Synthesis of 4-Aryl-3,4-dihydropyrimidinones Using Microwave-assisted Solventless Biginelli Reaction[J]. Chinese Journal of Chemistry, 2002, 20(4): 385-389. DOI: 10.1002/cjoc.20020200417 |
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| Authors: | XUE Song SHEN Yan-Cai LI Ya-Li SHEN Xiao-Ming GUO Qing-Xiang |
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| Affiliation: | XUE,Song SHEN,Yan-Cai LI,Ya-Li SHEN,Xiao-Ming GUO,Qing-XiangDepartment of Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China |
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| Abstract: | 4‐Aryl‐3, 4‐dihydropyrimidinones were synthesized using microwave‐assisted, solvent‐free protocol of the Biginelli reaction. The simple method provides the title compounds in 78%‐95% yields by the reaction of aromatic aldehydes with ethyl acetoacetate and urea/thiourea in the presence of a catalytic amount of conc. HCl. Lewis acids, such as ZnCl2, SnCl2, FeCl3·6H2O, and CuCl2·2H2O, were also found to be efficient catalysts for the synthesis of dihydropyrimidinones. |
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| Keywords: | dihydropyrimidinones microwave irradition Biginelli reaction |
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