Synthesis of catechins via thiourea/AuCl(3)-catalyzed cycloalkylation of aryl epoxides |
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| Authors: | Liu Yongxiang Li Xiben Lin Guang Xiang Zheng Xiang Jing Zhao Mingzhe Chen Jiahua Yang Zhen |
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| Affiliation: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), School of Pharmaceutical Science, Peking University, Beijing, China. |
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| Abstract: | A diversity-oriented approach for the synthesis of structurally diverse catechins was achieved in good yields via thiourea/AuCl(3)/AgOTf-catalyzed annulations of aryl epoxides under mild conditions. This new protocol provides a highly efficient entry to a library of catechins-derived natural products, notably anti-HIV agent 8-C-ascorbyl-(-)-epigallocatechin. |
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