| 载有5-氟脲嘧啶高分子药物的合成、结构及性能的研究 |
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| 引用本文： | 周朝华,杨福顺. 载有5-氟脲嘧啶高分子药物的合成、结构及性能的研究[J]. 高等学校化学学报, 1987, 8(1): 87 |
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| 作者姓名： | 周朝华 杨福顺 |
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| 作者单位： | 兰州大学化学系 |
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| 摘 要： | 用可溶性淀粉或羧甲基纤维素作载体,合成了侧链连有5-氟脲嘧啶的四个系列的高分子载体药物;用分子筛作催化剂合成了两种新的5-氟脲嘧啶衍生物,利用IR、1HNMR和质谱确定了它们的结构;研究了高分子药物含氮量随反应条件的变化规律及对其特性粘度的影响;并模拟生理条件在不同pH的缓冲溶液中对5-氟脲嘧啶的水解释放率进行了系统考查,对个别淀粉衍生物进行了生物活性测定。
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| 收稿时间： | 1985-05-23 |
Synthesis,Structure and Behavior of Polymeric Drugs Covalently Linked 5-Fluorouracil |
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| Zhou Chaohua,Yang Fushun. Synthesis,Structure and Behavior of Polymeric Drugs Covalently Linked 5-Fluorouracil[J]. Chemical Research In Chinese Universities, 1987, 8(1): 87 |
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| Authors: | Zhou Chaohua Yang Fushun |
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| Affiliation: | Department of Chemistry, Lanzhou University, Lanzhou |
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| Abstract: | Four scries of macromolocular drugs covalently. linked 5-fluorouracil(5-FU) are synthesized by the use of soluble starch and carboxylmcthylccllulose as carries, and two new 5-FUderivatives by the use of molecular sieve as catalyst. Their structure arc determined by R, 1HNMR and mass spectra. The changes for the nitrogen content of polymeric drugs with reactions and the influence of the Ncontent on their limiting viscosily arc studied. The hydrolysis delivery of 5-FUfrom starch and carboxymethyl-cellulose derivatives in various of buffer arc researched by moulding physiologicaly acid-alkali enviroment. In addition, antican-car activity (in vivo and in vitro) of some starch derivative has been prelimina-ryly observed. |
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