High-Yield Hypocrellin A Production in Solid-State Fermentation by <Emphasis Type="Italic">Shiraia</Emphasis> sp. SUPER-H168 |
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| Authors: | Yujie Cai Xiaohui Liang Xiangru Liao Yanrui Ding Jun Sun Xiaohui Li |
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| Institution: | (1) Key Laboratory of Industrial Biotechnology, School of Biotechnology, Jiangnan University, 1800 Lihu road, Wuxi, Jiangsu, China, 214122;(2) School of Information Technology, Jiangnan University, Wuxi, Jiangsu, China, 214122;(3) School of Food Science, Shanghai Ocean University, Shanghai, China, 201306 |
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| Abstract: | Hypocrellin A production by Shiraia sp. SUPER-H168 was studied under solid-state fermentation. Corn was found to be the best substrate after evaluating eight
kinds of agro-industrial crops and residues. The optimized solid-state fermentation conditions were as follows: inoculum size
3 × 106 spores, substrate particle size 0.8–1 mm, initial moisture content 50%, and temperature 30 °C. Six kinds of external carbon
source and seven kinds of external nitrogen source were evaluated, respectively, for HA production. Glucose and NaNO3 were the best. The combination of them was optimized by the response surface method. The optimum compositions of the supplementary
glucose and NaNO3 were 1.65 g/100 g and 0.43 g/L, respectively. Hypocrellin A production reached 4.7 mg/g. |
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