| 用^3HNMR波谱法分析微波激发催化交换制备的^3H标记颠茄类生物碱 |
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| 引用本文： | 张丽明,郑冬珠.用^3HNMR波谱法分析微波激发催化交换制备的^3H标记颠茄类生物碱[J].分析测试学报,1993,12(3):22-26. |
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| 作者姓名： | 张丽明 郑冬珠 |
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| 作者单位： | 中国科学院上海原子核研究所
(张丽明，郑冬珠，蒋晓马，袁建民)，中国科学院上海原子核研究所(赵夏令) |
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| 摘 要： | 用~3H NMR波谱法测定了微波激发催化交换制备的四种~3H标记颠茄类生物碱示踪剂的氚标记位置及其相对百分含量。并在用~1H NMK归属原料纯度及标记物分子各基因化学位移时采用了水峰抑制技术(简称WEFT),既能同时消除溶剂氘代甲醇及水峰的影响;又能提高灵敏度(近10倍),从而计算出所得标记产物的化学纯度值与放化纯度值。为快速、准确寻找制备标记生物碱的最佳实验条件和控制标记物质量提供了唯一的物理无损分析方法。
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| 关 键 词： | NMR 颠茄类 生物碱 示踪剂 |
~3H NMR Analysis on ~3H-Labelled Belladdnna Alkaloids by Microwave Excitation with Catalysed Exchange Method |
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| Zhang Liming,Zheng Donzhu,Yuan Jiming,Jia Xiaoma,Zhao Xioling.~3H NMR Analysis on ~3H-Labelled Belladdnna Alkaloids by Microwave Excitation with Catalysed Exchange Method[J].Journal of Instrumental Analysis,1993,12(3):22-26. |
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| Authors: | Zhang Liming Zheng Donzhu Yuan Jiming Jia Xiaoma Zhao Xioling |
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| Institution: | Zhang Liming,Zheng Donzhu,Yuan Jiming,Jia Xiaoma,Zhao Xioling Shanghai Institute of Nuclear Research,Academia Sinica,Shanghai,201800 |
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| Abstract: | A rapid, high effect and specific labelling method in the effective component of some bella-donna alkaloids was suggested and their labelling positions were studied by using ~3H NMR & ~1HNMR. ~3H NMR showed that the tritium was basically confined to stable aromatic position andtheir chemical purity was 75-80 per cent by ~1H NMR analysis. |
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| Keywords: | ~3H NMR spectrum ~3H-labelled belladonna alkaloids WEFT |
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