| GC—MS定量测定大鼠血,脑中的氯胺酮和二甲苯胺噻嗪 |
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| 引用本文： | 刘锋 胡绪英. GC—MS定量测定大鼠血,脑中的氯胺酮和二甲苯胺噻嗪[J]. 分析测试学报, 1993, 12(1): 26-30 |
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| 作者姓名： | 刘锋 胡绪英 |
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| 作者单位： | 军事医学科学院毒物药物研究所 北京(刘锋，胡绪英)，军事医学科学院毒物药物研究所 北京(李前远) |
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| 摘 要： | 描述了大鼠血、脑中氯胺酮和二甲苯胺噻嗪同时测定的定量分析方法。该法用溶剂同时提取血中或脑中的氯胺酮和二甲苯胺噻嗪,并在气相色谱上与杂质有效分离。方法简单、可靠、灵敏度高。已用于给药后大鼠血、脑中氯胺酮和二甲苯胺噻嗪的定量测定,得到了有意义的结果。
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| 关 键 词： | 氯胺酮 二甲苯胺噻嗪 血 脑 |
Quantitative Analysis Ketamine and Xylazine in Plasma and Brain Homogenate of Rats by GC-MS |
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| Liu Feng,Hu Xuying,Li Qianyuan Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences. Quantitative Analysis Ketamine and Xylazine in Plasma and Brain Homogenate of Rats by GC-MS[J]. Journal of Instrumental Analysis, 1993, 12(1): 26-30 |
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| Authors: | Liu Feng Hu Xuying Li Qianyuan Institute of Pharmacology Toxicology Academy of Military Medical Sciences |
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| Abstract: | Ketamine and xylazine were extracted from plasma or brain homogenate of rats and thenseparated by GC. Quantitation was achieved using mass chromatogram. The detection limit in1mL plasma or 0.5mL brain homogenate for ketamine is 25ng and for xylazine is 50ng. |
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| Keywords: | Ketamine Xylazine GC-MS Plasma and brain |
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