Studies on the stereoselective synthesis of C-allyl glycosides |
| |
Authors: | McGarvey Glenn J LeClair Christopher A Schmidtmann Bahar A |
| |
Affiliation: | Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA. gjm@virginia.edu |
| |
Abstract: | An investigation was carried out to explore the use of sulfoxide donors as common precursors to stereoisomeric C-glycoconjugates of glycoprotein and glycolipid tumor antigens. A study focusing on the effects of reaction conditions and substrate structure on the stereoselectivity of allylation was carried out. Although conditions were realized to selectively afford alpha-allylation products in good to excellent yields, the search for conditions favoring beta-selectivity proved less successful. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|