Difluoromethylation of Sulfonamides |
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| Authors: | Petko K I Tolmachev A A Yagupol'skii L M |
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| Institution: | (1) Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02094, Ukraine |
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| Abstract: | Reactions of sulfonamides RSO2NHR' with chlorodifluoromethane and solid alkali give the corresponding derivatives RSO2N(CHF2)R' containing a difluoromethyl group on the nitrogen atom. Sulfonamides derived from 2-aminobenzothiazole and 2- and 4-aminopyridines react with chlorodifluoromethane at the endocyclic nitrogen atom. |
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