A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B |
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| Authors: | Smith Amos B Kürti Laszló Davulcu Akin H |
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| Institution: | Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, 19104, USA. smithab@sas.upenn.edu |
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| Abstract: | reaction: see text] Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns. |
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