Unusual ligand-dependent chemoselective Suzuki-Miyaura cross-coupling reactions of 3-bromo-4-trifloyl-thiophenes |
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| Authors: | Jizhou Wang Mark A. SeefeldJuan Luengo |
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| Affiliation: | Department of Medicinal Chemistry, Oncology R&D, GlaxoSmithKline, 1250 S. Collegeville Rd., Collegeville, PA 19426, USA |
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| Abstract: | An unusual ligand-dependent chemoselective Suzuki-Miyaura cross-coupling reaction for 3-bromo-4-trifloyl-thiophenes was discovered. Pd(PPh3)4 showed selectivity for triflate over bromide, whereas the selectivity was reversed for Pd(tBu3P)2. |
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