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Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles containing benzothiazolylthiol grouping
Authors:V I Kelarev  M A Silin  N A Grigor'eva  V N Koshelev
Abstract:A series of 2,5-substituted 1,3,4-oxadiazoles containing 2-benzothiazolylthiomethyl grouping has been synthesized by condensing derivatives of (2-benzothiazolylthio)acetic acid with imino ester hydrochlorides and hydrazides of carboxylic acids, by the cyclodehydration of N-acyl-Nprime-(2-benzothiazolylthioacetyl)hydrazines under the action of POCl, and also by the reaction of 2-mercaptobenzothiazole with 2-chloromethyl-1,3,4-oxadiazoles in the presence of sodium methylate.I. M. Gubkin Russian State University for Petroleum and Gas, Moscow 117917. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 249–255, February, 2000.
Keywords:benzothiazole  carboxylic acid hydrazides  carboxylic acid imino ester hydrochlorides  2-mercaptobenzothiazole  1  3  4-oxadiazole  condesation
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