Coulometric titration of some phenolic steroids with bromine based on thin-layer hydrodynamic biamperometric end-point detection |
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Authors: | MA de Soto Perera DJ Curran |
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Institution: | Department of Chemistry, GRC Tower I, University of Massachusetts, Amherst, MA 01003 U.S.A. |
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Abstract: | Four phenolic steroids were titrated coulometrically with bromine in a methanol—water solvent containing hydrochloric acid and sodium bromide. End-point detection was achieved with a twin electrode thin-layer cell placed in a flow loop connected to the titration vessel. Linear-segmented biamperometric titration curves were recorded. Concentrations of 17-β-estradiol were determined in the range from 442 ppb to 8.84 ppm with relative inaccuracies of -1.3% and +2.2%, respectively. Part-per-million solutions of estrone and estriol were titrated with good accuracy and precision. Somewhat poorer precision and accuracy was found for the determination of 17-α-ethynyl estradiol. |
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