REVIEW: metal complexes as urease inhibitors |
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Authors: | Ladislav Habala Ferdinand Devínsky Alexander E Egger |
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Institution: | 1. Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University Bratislava, Slovakiahabala@fpharm.uniba.sk;3. Faculty of Pharmacy, Department of Chemical Theory of Drugs, Comenius University Bratislava, Slovakia;4. Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria |
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Abstract: | Urease plays a significant role in the pathogenesis of several diseases and also has practical implications in other fields, such as agriculture or chemical analysis. Among the multitude of chemical species known to inhibit urease, metal complexes stand out as a special category due to their specific mechanism of action, distinct from purely organic substances. Their inhibitory activity seems to depend on the type of metal and its oxidation state as well as on the coordination environment of the central atom. Furthermore, the study of the interaction between metal ions and their complexes with urease renders valuable insights into detailed catalytic mechanisms of this enzyme. This brief survey attempts to provide an overview of the published research on urease inhibition by metal complexes. |
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Keywords: | Urease enzyme inhibitors metal complexes metallopharmaceuticals bioinorganic chemistry ureolytic bacteria |
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