Synthesis,spectral characterization,and in vitro antimicrobial activity in liquid medium and applied on cotton fabric of a new PAMAM metallodendrimer |
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| Authors: | Ivo Grabchev Evgenia Vasileva-Tonkova Desislava Staneva Paula Bosch Rositsa Kukeva Radostina Stoyanova |
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| Institution: | 1. Faculty of Medicine, Sofia University “St. Kliment Ohridski”, Sofia, Bulgariai.grabchev@chem.uni-sofia.bg;3. Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria;4. Department of Fundamentals of Chemical Technology, University of Chemical Technology and Metallurgy, Sofia, Bulgaria;5. Department of Macromolecular Chemistry, Institute of Science and Technology of Polymers, CSIC, Madrid, Spain;6. Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria |
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| Abstract: | A new polyamidoamine metallodendrimer modified with eight 1,8-naphthalimide units was synthesized. The Cu(II) complex has been investigated by EPR spectroscopy and it has shown that 17 copper ions have involved in the dendrimer complex. To confirm the presence of metallodendrimers on the cotton surface, scanning electron microscopy characterization has been used. In vitro antimicrobial activity of the metallodendrimer against different pathogens was investigated and compared to the dendrimer ligand free of copper ions. Both dendrimers were deposited on a cotton fabric and antibacterial activity of the treated cotton samples was investigated against model Gram-positive and Gram-negative bacteria. It has been shown that the studied dendrimers reduce bacterial growth and prevent the formation of biofilms. The metallodendrimer showed stronger antimicrobial and biofilm inhibiting abilities than those of the free of Cu(II) ions ligand. |
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| Keywords: | 1 8-Naphthalimides antibacterial textile biofilm metallodendrimers SEM |
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