Recent advances in the synthesis of C-5-substituted analogs of 3,4-dihydropyrimidin-2-ones: A review |
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Authors: | Sanjay K. Rathwa Mahesh S. Vasava Manoj N. Bhoi Mayuri A. Borad |
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Affiliation: | Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India |
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Abstract: | 3,4-Dihydropyrimidin-2-ones act as a versatile scaffold in organic synthesis, which serves as a significant template for the development of various therapeutic agents and shows a wide spectrum of activities. The attractive application of 3,4-dihydropyrimidin-2-ones in organic synthesis is undoubtedly owing to C-5 ester group, which is responsible for the change in its bioactivity. Introduction of various groups like electron-withdrawing and electron-donating groups at positions 1, 2, 3, 5, and 6 greatly increased biological activity. Significant efforts have been undertaken to exploit different synthetic routes to synthesize various derivatives of 3,4-dihydropyrimidin-2-ones. This review article gives a comprehensive account of the synthetic utility of C-5 substitution of 3,4-dihydropyrimidin-2-ones used in the design and synthesis of different types of compounds with greater emphasis on recent literature. |
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Keywords: | 3,4-Dihydropyrimidin-2-ones Biginelli reaction dihydropyrimidinone heterocyclic compounds multicomponent reaction organic synthesis |
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