Competitive potentiometric determination of binding constants between α-cyclodextrin and 1-alkanols |
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Authors: | Noriaki Funasaki Makoto Nagaoka Shun Hirota |
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Affiliation: | Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan |
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Abstract: | The binding constants of 1-alkanols with α-cyclodextrin (α-CD) were determined by indirect competitive potentiometry, although potentiometry is usually inapplicable to nonionic compounds. This novel method utilizes competitive binding of 1-alkanol and octyltrimethylammonium bromide (OTAB) to α-CD in aqueous media, where the concentration of free OTAB depending on the competitive binding is monitored with an OTAB-selective electrode. Therefore, the concentration of 1-alkanol is indirectly estimated from the observed electromotive force. The binding constants of 1-propapnol, 1-butanol, 1-hexanol, and 1-octanol with α-CD, obtained by this method, are close to the literature values. The implications and limitations of this indirect competitive potentiometry were discussed. |
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Keywords: | Indirect competitive potentiometry Binding constant 1-Alkanol α-Cyclodextrin |
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