AFM study of a new carrier based on PLA and salen copolymers for gene therapy |
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| Authors: | Nadeau Véronique Hildgen Patrice |
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| Institution: | Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, (Québec), Canada. |
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| Abstract: | The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge. |
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