| An Environmentally-Friendly and Catalytic Procedure for Mukaiyama Aldol Reaction Using Organic Catalyst DBU under Solvent Free Conditions |
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| 作者姓名： | SHEN Zhi-Liang
JI Shun-Jun
LOH Teck Peng |
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| 作者单位： | SHEN,Zhi-Liang（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006;Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543）
JI,Shun-Jun（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
LOH,Teck Peng（Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006;Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543） |
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| 基金项目： | 国家自然科学基金，Foundation of National University of Singapore |
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| 摘 要： | Recently, methods based exclusively on organic catalysts have become of major significance in synthetic chemistry.Mukaiyama-aldol reaction, as one of the most important and frequently utilized methods for C-C bond formation, is well documented in literatures recently. A variety of reagents, particularly metal-containing Lewis acids or bases, are known to promote the nucleophilic process. However, many of the reported strategies might have the following limitations from environmental viewpoints: (1) the use of metal-containing catalyst. Some of the catalysts are air or moisture sensitive (such as lithium amide), and crucial reaction conditions are needed; Some of the catalysts derived from poisonous metal (for example: SnCl4, SmI2 etc.) may cause harmful influence on humane body and environment; (2) the use of organic solvent (such as DMF, CH2Cl2 etc.) may bring about environmental pollution and solvent waste.
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An Environmentally-Friendly and Catalytic Procedure for Mukaiyama Aldol Reaction Using Organic Catalyst DBU under Solvent Free Conditions |
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| SHEN,Zhi-Liang,JI,Shun-Jun,LOH,Teck Peng.An Environmentally-Friendly and Catalytic Procedure for Mukaiyama Aldol Reaction Using Organic Catalyst DBU under Solvent Free Conditions[J].Chinese Journal of Organic Chemistry,2004,24(Z1):264. |
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| Authors: | SHEN Zhi-Liang JI Shun-Jun LOH Teck Peng |
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| Abstract: | Recently, methods based exclusively on organic catalysts have become of major significance in synthetic chemistry.Mukaiyama-aldol reaction, as one of the most important and frequently utilized methods for C-C bond formation, is well documented in literatures recently. A variety of reagents, particularly metal-containing Lewis acids or bases, are known to promote the nucleophilic process. However, many of the reported strategies might have the following limitations from environmental viewpoints: (1) the use of metal-containing catalyst. Some of the catalysts are air or moisture sensitive (such as lithium amide), and crucial reaction conditions are needed; Some of the catalysts derived from poisonous metal (for example: SnCl4, SmI2 etc.) may cause harmful influence on humane body and environment; (2) the use of organic solvent (such as DMF, CH2Cl2 etc.) may bring about environmental pollution and solvent waste. |
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