| Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile |
| |
| 引用本文： | XiangGuoSHI DaFangZHONG YuMingSUN YuFengZHANG. Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile[J]. 中国化学快报, 2004, 15(4): 431-434 |
| |
| 作者姓名： | XiangGuoSHI DaFangZHONG YuMingSUN YuFengZHANG |
| |
| 作者单位： | LaboratoryofDrugMetabolismandPharmacokinetics,ShenyangPharmaceuticalUniversity,Shenyang110016 |
| |
| 摘 要： | A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry(LC/ESI-MS^n).Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as M1 serial(spiramycin Ⅰ，Ⅱ，Ⅲ),M2 serial(platenomycin A1,josamycin and leucomycin A1) and M3 serial(deisovalerylplatenomycin A1,deisovaleryljosamycin,deisovalerylleucomycin A1).
|
| 关 键 词： | 代谢物 抗生素 螺旋霉素 鼠尿 胆汁 |
Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile |
| |
| Xiang Guo SHI,Da Fang ZHONG,Yu Ming SUN,Yu Feng ZHANGLaboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical University,Shenyang. Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile[J]. Chinese Chemical Letters, 2004, 15(4): 431-434 |
| |
| Authors: | Xiang Guo SHI Da Fang ZHONG Yu Ming SUN Yu Feng ZHANGLaboratory of Drug Metabolism Pharmacokinetics Shenyang Pharmaceutical University Shenyang |
| |
| Affiliation: | Xiang Guo SHI,Da Fang ZHONG,Yu Ming SUN,Yu Feng ZHANGLaboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical University,Shenyang 110016 |
| |
| Abstract: | |
| |
| Keywords: | Spiramycin bitespiramycin metabolites. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
