| Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile |
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| 作者姓名： | XiangGuoSHI DaFangZHONG YuMingSUN YuFengZHANG |
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| 作者单位： | LaboratoryofDrugMetabolismandPharmacokinetics,ShenyangPharmaceuticalUniversity,Shenyang110016 |
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| 摘 要： | A sensitive analytical method to identify active metabolites of bitespiramycin in rat urine and bile was developed by liquid chromatography-electrospray ionization tandem mass spectrometry(LC/ESI-MS^n).Bitespiramycin and its major active metabolites in rat urine and bile were isolated and identified as M1 serial(spiramycin Ⅰ，Ⅱ，Ⅲ),M2 serial(platenomycin A1,josamycin and leucomycin A1) and M3 serial(deisovalerylplatenomycin A1,deisovaleryljosamycin,deisovalerylleucomycin A1).
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| 关 键 词： | 代谢物 抗生素 螺旋霉素 鼠尿 胆汁 |
Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile |
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| XiangGuoSHI DaFangZHONG YuMingSUN YuFengZHANG.Metabolites of A Novel Antibiotic Bitespiramycin in Rat Urine and Bile[J].Chinese Chemical Letters,2004,15(4):431-434. |
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| Authors: | Xiang Guo SHI Da Fang ZHONG Yu Ming SUN Yu Feng ZHANG
Laboratory of Drug Metabolism and Pharmacokinetics Shenyang Pharmaceutical University Shenyang |
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| Institution: | Xiang Guo SHI,Da Fang ZHONG,Yu Ming SUN,Yu Feng ZHANG
Laboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical University,Shenyang 110016 |
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| Abstract: | |
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| Keywords: | Spiramycin bitespiramycin metabolites |
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