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The convergent synthesis of novel cytotoxic certonardosterol D2 from diosgenin |
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| Authors: | Biao Jiang He-ping Shi Wei-sheng Tian Wei-shan Zhou |
| Institution: | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fengling Road, Shanghai 200032, PR China |
| Abstract: | Certonardosterol D2, a polyhydroxysterol isolated from starfish Certonardoa semiregularis with exceptionally potent antitumor activity, was stereoselectively synthesized from natural rich diosgenin via the protocol of Julia olefination and Evans aldol reaction. |
| Keywords: | Polyhydroxysterol Certonardosterol Julia olefination Evans aldol reaction |
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