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Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines |
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| Authors: | Ian G Macreadie Thomas D Avery Peter Macreadie Dennis K Taylor Edward RT Tiekink |
| Institution: | a Department of Chemistry, The University of Adelaide, 5005 South Australia, Australia b CSIRO, Molecular and Health Technologies, Parkville, 3052 Victoria, Australia c Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78248-0698, USA |
| Abstract: | In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported. |
| Keywords: | Antifungal 1 2-Dioxine Candida Epoxy-1 2-dioxine Haemolytic activity |
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