Multicomponent and one-pot synthesis of trisubstituted pyridines through a Pd-catalyzed cross-coupling/cross-coupling/cycloaddition sequence |
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Authors: | José Barluenga |
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Institution: | Instituto Universitario de Química Organometálica ‘Enrique Moles’, Unidad asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo, Spain |
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Abstract: | Trisubstituted pyridines are regioselectively synthesized through multicomponent and one-pot processes promoted by a bifunctional Pd-catalyst. The process involves formation of an enamine by Pd-catalyzed amination of an alkenyl bromide, formation of a 2-aza-1,3-butadiene by Pd-catalyzed cross-coupling of a trimethylsilylimine with an alkenyl bromide, and Lewis acid catalyzed cycloaddition between the enamine and the azadiene. |
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