Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius |
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| Authors: | Sheng-Ping Yang |
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| Affiliation: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China |
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| Abstract: | Four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C-F (1-4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C-F (1-4) exerted potent and selective inhibition on the delayed rectifier (IK) K+ current with the IC50 values of 3.6±10.1, 2.7±0.3, 27.5±5.1 and 57.5±6.1 μM, respectively. |
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| Keywords: | Chlorahololides C-F Potassium channel blocker Structural elucidation Chloranthus holostegius |
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