New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite |
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| Authors: | Xueyan Yang Xianjin Yang Yizheng Han Fanhong Wu |
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| Affiliation: | a Laboratory for Advanced Material and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PR China |
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| Abstract: | Difluoroiodomethylsulfanylbenzene (3a) and 1-chloro-4-difluoroiodomethylsulfanylbenzene (3b) are novel and efficient difluoromethylating reagents via the reaction with unsaturated compounds, such as alkenes, ethynylbenzene, pent-4-en-1-ols, and pent-4-enoic acids initiated by Na2S2O4, to afford the corresponding adducts, tetrahydrofuran derivatives, and γ-butyrolactones containing difluoromethylene group in moderate to good yields. |
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| Keywords: | Difluoroiodomethylsulfanylbenzene Difluoromethylene γ-Butyrolactone Addition Tetrahydrofuran derivatives |
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