Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides |
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| Authors: | Stefania Fioravanti Paolo A. Tardella |
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| Affiliation: | Dipartimento di Chimica, Università degli Studi ‘La Sapienza’, P.le Aldo Moro 2, I-00185 Roma, Italy |
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| Abstract: | Starting from a library of 2-l-α-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amido aziridinyl peptides, potential protease inhibitors, were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. |
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