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Xenimanadins A-D, a family of xenicane diterpenoids from the Indonesian soft coral Xenia sp. |
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| Authors: | Ernesto Fattorusso Orazio Taglialatela-Scafati M. Janib Achmad Giorgio Bavestrello |
| Affiliation: | a Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli ‘Federico II’, Via D. Montesano 49, 80131 Napoli, Italy b Faculty of Fisheries and Marine Sciences, Sam Ratulangi University, 95115 Manado, Indonesia c Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy d Dipartimento per lo Studio del Territorio e delle sue Risorse, Università di Genova, Corso Europa 26, 16132 Genova, Italy |
| Abstract: | Four novel xenicane diterpenoids, xenimanadins A-D (1-4), characterized by the unusual 2,6-dimethoxytetrahydropyran functionality, have been isolated from the Indonesian soft coral Xenia sp., together with three known xeniolides. The stereostructure of these metabolites has been established through extensive interpretation of NMR data and application of the modified Mosher method. Xenimanadins were tested against tumor cell lines, revealing details about the cytotoxic potential of xenicane diterpenoids. |
| Keywords: | Xenia soft corals Indonesia Diterpenes Structure elucidation NMR |
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