Preparation and conformational study of CF3-containing enkephalin-derived oligopeptide |
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| Authors: | Takamasa Kitamoto |
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| Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei 184-8588, Japan |
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| Abstract: | Incorporation of (2S,3S)-4,4,4-trifluorothreonine (F3-Thr) instead of Thr in the enkephalin-derived hexapeptide led to the apparent conformational alteration due to the strong electron-withdrawing effect of the trifluoromethyl group by comparison with the original compound on the basis of their various NMR measurements. |
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| Keywords: | Fluorinated amino acid Peptides Conformations NOESY spectra |
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