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Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone |
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| Authors: | Prabhakar Bachu |
| Affiliation: | Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand |
| Abstract: | The asymmetric synthesis of (−)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435® as the key step. |
| Keywords: | Eleutherin Thysanone Topoisomerase II inhibitor 3C-protease inhibitor Novozyme 435® (Candida antarctica lipase) Microwave assisted lipase kinetic resolution Intramolecular cyclization |
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