Kinetics of oxidative deamination of some amino acids by diperiodatoargentate(III) in alkaline medium

Kinetics of oxidation of some amino acids, viz. glycine, alanine, valine, leucine, phenylglycine and phenylalanine by diperiodatoargentate(III) have been investigated in alkaline medium. The order of the reaction is found to be one with respect to each reactant. The reaction rates are inversely dependent on both OH^–] and periodate]. The oxidation products are found to be ammonia and the corresponding keto acids. The presence of electron-withdrawing groups at the -carbon increases the rate of oxidation while the rate decreases with increasing alkyl chain length. A two-electron-transfer mechanism is proposed to explain the results.

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